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Onco-this-Week: Special Report from ASCO 2018

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Editor’s Note: This issue of Onco-this-Week presents 50+ updates from ASCO 2018 meeting (Chicago, IL) which includes several studies like DUO, MAVORIC, ADMYRE, KEYNOTE-006, -042, -158, 184, -427, -524, -526, TOPACIO, QUADRA, ARCHER 1050, VISION, EMPOWER-CSCC-1, ZUMA-1, -3, COLUMBUS, Study 08, CAPTIVATE, RELEVANCE, MONALEESA-3, ALEX, CELESTIAL, Checkmate-227, JAVELIN Merkel 200, TRANSCEND, MURANO, OPTIMISMM, ICONIC, IMPACT, SANDPIPER, LIBRETTO-001, ENESTop and ENEST freedom trials. If you are interested to know more about the detailed analysis of each news, Richa has provided a downloadable report which can be accessed from the link provided after the editorial note. We have also included a bit of history about ASCO and the educational video that traces the past, present and future vision of ASCO. In the infographics section, we present a timeline spanning ages about the documented history of Breast Cancer and its treatment from 1600BC to the recent years.- Abhi Dey

For a downloading a detailed report by Richa click ASCO 2018

About ASCO’s History

“In 1964, a group of seven cancer physicians banded together with a single purpose—to improve the care of people with cancer. At the time, cancer was viewed as a monolithic and frequently incurable disease, with only a handful of hard-to-tolerate and mostly ineffective therapies available. Stigma and silence left many patients with cancer with little support or information.

ASCO has held true to this vision. Over five decades, ASCO and its members have established and advanced the field of modern clinical oncology. In many ways, the story of ASCO is the story of progress against cancer. As ASCO grew from its original seven members to more than 40,000 today, national funding for cancer research increased from less than $200 million to more than $5 billion annually. The number of drugs available to treat cancer grew from just a handful to more than 170. And, most importantly, patients are living longer and better lives. ASCO’s memberstogether with patients with cancer, patient advocates, and the policymakers, government agencies, and philanthropic organizations like the Conquer Cancer Foundation that have invested in vital research, have enabled and delivered these remarkable advances.”- Source

Educational Video: About ASCO completing 50 years in 2014 https://video.asco.org/9aafb6d6-adf1-4645-8992-36fa5d8eb989

This edition of Onco-this-Week is Sponsored by Nano-Tag Biotechnologies

 

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Note from our Sponsor: “Our single-domain antibody-based Tags are significantly lighter than conventional IgGs. 1 µg of Tag will therefore contain ~10-times more molecules than 1 µg of a conventional antibody.To know more contact us.”

“NanoTag Biotechnologies is a German company founded in July 2015 by scientists with a strong background in biochemistry as well as quantitative super-resolution imaging. Situated in Göttingen, we are in constant exchange with scientists developing and applying tools for innovative cutting-edge research. The inspiring atmosphere created by leading scientists and an excellent network of entrepreneurship is an ideal breeding ground for our vision to produce thoroughly validated high-quality tools for life-sciences, biotechnology and bio-medical research. Currently, our portfolio mainly focuses on single-domain antibody-based affinity reagents (“Tags”) for biochemical and fluorescence-based applications. In the near future, we are going to expand our portfolio to enzymes, affinity resins and secondary reagents for various immunoassays (IP, IF, IHC, IHC-P, WB…). Feel free to contact us anytime to discuss custom projects.”
Cover image: [Courtesy: Felipe Opazo (CEO) Nano-Tag Biotechnologies]3T3 cells transfected with the mitochondrial marker TOM70-mTagBFP, stained with FluoTag-X2 anti-TagFP Atto542 (red) and DAPI (blue). Due to the weak expression of the mTagBFP marker, only the DAPI signal is visible in the blue channel.(For more info click here)

NEWS

(To know more about every news item, click on the individual title points)

  1. Verastem Oncology presents data on two lead drug candidates
  2. Kyowa Kirin presents new data for Mogamulizumab from Its lead program in Cutaneous T-cell Lymphoma (CTCL)
  3. PharmaMar presents in oral session at ASCO the ADMYRE study’s adjusted overall survival with plitidepsin
  4. Dynavax reports data for Ph 1b/2 trial of SD-101 in combination with pembrolizumab in Advanced Melanoma
  5. PharmaMar presents new results with lurbinectedin as a single agent in patients with recurrent small-cell lung cancer
  6. TESARO summarizes TOPACIO and QUADRA trial results
  7. Dacomitinib Shows More than Seven-Month Improvement in Overall Survival Compared to an Established Therapy in Advanced NSCLC with EGFR-Activating Mutations
  8. NewLink Genetics Announces Final Results from Two Phase 2 Studies of Indoximod Presented at ASCO 2018
  9. Endocyte Announces Enrollment of First Patient in Phase 3 VISION Trial of 177Lu-PSMA-617 in Prostate Cancer
  10. Adaptimmune presents detailed safety update from ongoing MAGE-A10 pilot studies
  11. Kite Announces Initial Results From a Phase 1 Study of T Cell Receptor (TCR) Cell Therapy in HPV-16-Positive Solid Tumors
  12. First presentation of LENVIMA/KEYTRUDA data in patients with unresectable HCC, which aims to be the first systemic combination of a TKI and immunotherapy for these patients, as well as SCCHN
  13. Pivotal cemiplimab trials showing positive results in advanced cutaneous squamous cell carcinoma presented
  14. Merck’s KEYTRUDA® (pembrolizumab) Showed Promising Anti-Tumor Activity in Patients with Advanced Small Cell Lung Cancer (SCLC) in Phase 2 KEYNOTE-158 Study
  15. Kite announces new data analyses for CAR T therapy in patients with Blood Cancers
  16. Array BioPharma Announces Additional Median Overall Survival Results of Encorafenib and Binimetinib in Patients with BRAF-mutant Advanced Melanoma
  17. Merck’s KEYTRUDA® (pembrolizumab) Demonstrated Long-Term Survival Benefit Based on Four and Five Years of Follow-Up from Two Pivotal Studies in Advanced Melanoma
  18. Opdivo (nivolumab) 3 mg/kg Demonstrates Sustained, Superior Recurrence-Free Survival Versus Yervoy (ipilimumab) 10 mg/kg for Broad Range of Patients with Resected Stage III or IV Melanoma
  19. Lynparza in combination with abiraterone delayed disease progression in metastatic castration-resistant prostate cancer
  20. Merck presents updated results from expansion cohorts of the ongoing M7824 Ph I trial (NCT02517398) of Bifunctional Immunotherapy M7824
  21. Preliminary data for NKTR-214 in combination with Nivolumab for patients with stage IV metastatic melanoma, RCC, and urothelial cancers
  22. Ph II ibrutinib + venetoclax early data show high rates of responses in 1L CLL patients
  23. Merck’s KEYTRUDA® (pembrolizumab) Showed Overall Response Rate of Nearly 40 Percent as First-Line Therapy in Patients with Advanced Clear Cell Renal Cell Carcinoma (RCC) in Phase 2 KEYNOTE-427 Study
  24. Results of Phase III RELEVANCE Study Comparing REVLIMID plus Rituximab (R²) Versus Rituximab Plus Chemotherapy in Patients with 1L Follicular Lymphoma
  25. Third Novartis Phase III trial shows Kisqali® combination therapy significantly improves PFS in HR+/HER2- advanced breast cancer
  26. Updated ALEX trial results show alectinib further outpacing crizotinib in treatment naive ALK+ NSCLC
  27. KEYTRUDA® (pembrolizumab) Monotherapy Significantly Improved Overall Survival in KEYNOTE-042 Study as First-Line Treatment for Locally Advanced or Metastatic NSCLC Patients Whose Tumors Expressed PD-L1 (TPS ≥1%)
  28. Erdafitinib shows promise in urothelial cancer patients with specific mutations
  29. Exelixis Announces Results from Sub-Group Analyses of the Phase 3 Pivotal CELESTIAL Trial of Cabozantinib for Advanced HCC
  30. Immunomedics Reveals Promising Data for Sacituzumab Govitecan in Patients Heavily Pretreated for Metastatic Estrogen Receptor-Positive Breast Cancer
  31. IMV Inc. (Formerly Immunovaccine Inc.) Presents New Positive Data From Phase 1b/2 Combination Clinical Trial in Advanced Ovarian Cancer
  32. Merck presents update on Tepotinib in advanced lung cancer
  33. Nivolumab + chemotherapy show improved PFS in 1L squamous and non-sq. NSCLC patients with PD-L1 <1% in CheckMate-227 study
  34. Two Year Update of Pivotal JAVELIN Merkel 200 Trial Shows Continued Durable Responses with Avelumab in MCC
  35. Celgene announces updated safety and efficacy data from the TRANSCEND trial of liso-cel (JCAR017) in patients with R/R B-cell non-Hodgkin Lymphoma
  36. Roche presents new data across a range of blood cancers
  37. anti-BCMA CAR T-cell therapy bb2121 adds nearly 1 year of PFS for heavily pretreated relapsed/refractory multiple myeloma in Ph I CRB-401 trial
  38. Pomalidomide triplet (Pomalidomide, bortezomib, and low‐dose dexamethasone) extends PFS in relapsed/refractory lenalidomide-exposed myeloma patients in Ph III OPTIMISMM trial
  39. Venetoclax/Carfilzomib combo highly effective for t(11;14) R/R myeloma
  40. Boston Biomedical, Inc. highlights presentations on investigational agents napabucasin and DSP-7888 (ombipepimut-S*)
  41. Daiichi Sankyo presents long-term Ph I results of DS-8201 in patients with HER2-expressing breast, gastric and other solid cancers
  42. Abstract describing use of Oregovomab in Pancreatic Cancer to be published in JCO
  43. Study design of CD205-Shuttle, a first-in-human trial of MEN1309/OBT076 presented
  44. Agios presents data from Ph I dose-escalation study of AG-881 in patients with IDH mutant positive advanced glioma and other solid tumors
  45. Updated data from Ivosidenib Ph I dose-escalation and expansion trial in IDH1m relapsed or refractory AML continue to show durable responses as a single agent
  46. Jounce Therapeutics presents preliminary efficacy data from ongoing Ph I/II ICONIC trial of JTX-2011 in patients with advanced cancers
  47. Moxetumomab pasudotox pivotal data in patients with previously-treated hairy cell leukemia presented
  48. Long-term IMPACT data find improved survival when targeted therapies matched to tumor-specific gene mutations
  49. Taselisib and fulvestrant combination slows growth of most common type of advanced breast cancer in SANDPIPER trial
  50. Loxo Oncology announces positive interim clinical data from LOXO-292 dose escalation Ph I LIBRETTO-001 trial in RET-altered cancers
  51. New Novartis data found nearly half of CML patients treated with Nilotinib remain in remission almost three years after stopping therapy
  52. Astellas and Seattle Genetics present Enfortumab Vedotin data in patients with locally advanced or metastatic Urothelial Cancer previously treated with checkpoint inhibitor therapy

 

Infographically Speaking….

Breakthroughs in Breast Cancer Research

From Visually.

 

 

About the Author: 

Richa earned her PhD at the National Brain Research Centre, India. For her thesis, she worked on the dreaded Glioblastoma multiforme. That was her first in-depth exposure to academic research in cancer biology. After her PhD, she expanded her research experience by working in the field of immunology at UCLA, USA. After her return to India, Richa switched to a corporate setting but continued her engagement with the cancer field. She is currently loving her work, which affords her the opportunity to continue developing her knowledge in the biomedical field of cancer. Outside of work, she enjoys watching, identifying and photographing birds.

Editor and Blog Design:

Abhi Dey

Abhi graduated from the Molecular Biophysics Unit of IISc (Bangalore, India) in 2011. As a Biomedical Scientist, he has worked with all three life-forms in his 13-year research career, viz., particulate, unicellular and multicellular. He is currently an Assistant Scientist at Emory University (Atlanta, GA) studying mechanisms of tumor recurrence in kids with brain tumors. As a postdoctoral fellow, he was the recipient of two Young Investigator Awards from Alex Lemonade Stand Foundation (Philadelphia, PA) and Rockland Immunochemicals. His current research has been funded by Northwestern Mutual Foundation (Milwaukee, WI), CURE Childhood Cancer Foundation (Atlanta, GA) and American Association for Cancer Research (AACR).  When he is not on the bench you will find him spending time with his family or exploring the world through traveling and blogging.

Image Sources: Wikipedia and Twitter

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Disclaimer: The authors and editors for Onco-this-week declare no financial benefits or remuneration from the sponsors. The sponsorships support the non-profit organization, PhD Career Support Group. The research conducted by authors and editors is a voluntary effort to popularize science for the public on behalf of PhD CSG.

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The contents of Club SciWri are the copyright of Ph.D. Career Support Group for STEM PhDs (A US Non-Profit 501(c)3, PhDCSG is an initiative of the alumni of the Indian Institute of Science, Bangalore. The primary aim of this group is to build a NETWORK among scientists, engineers, and entrepreneurs).

This work by Club SciWri is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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